A second chain of human CD8 is expressed on peripheral blood lymphocytes.

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A second chain of human CD8 is expressed on peripheral blood lymphocytes

Human CD8 has been thought to consist of disulfide-linked homodimers and homomultimers of a single polypeptide chain homologous to mouse and rat CD8 alpha. In contrast, mouse and rat CD8 are composed of disulfide-linked heterodimers of alpha and beta chains. We have now isolated and sequenced cDNA clones encoding a human homologue of mouse and rat CD8 beta. One such clone was inserted into an e...

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1988

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.168.6.1993